Pairing extinction training with vagus nerve stimulation reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex

IntroductionRelapse triggered by drug-associated cues remains a major challenge in treating substance use disorders, as extinction learning is often weak and context dependent. Vagus nerve stimulation (VNS) enhances learning-related plasticity and, when paired with extinction training, reduces cue-i...

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Principais autores:	Christopher Driskill, Lily Vu, Sophia Jalilvand, Frank Salazar, Laney Waydick, Neha Suji, Sanjana Tata, Aamna Khan, Zarin Hasan, Ria Nuna, Zara Kanwal, Neissa Molin, Sven Kroener
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Neuroscience
Assuntos:	amygdala cocaine extinction hippocampus paraventricular nucleus of the thalamus parvalbumin
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fnins.2026.1756644/full
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