Evaluating the immunologically “cold” tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models

Abstract Background Immune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the therapeutic response following immune checkpoint blockade (ICB) in immunologically “hot” tumors. However, immune dynamics in the low T-cell infiltrati...

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Автори:	Yun Lu, Hailey A. Houson, Carlos A. Gallegos, Alessandro Mascioni, Fang Jia, Argin Aivazian, Patrick N. Song, Shannon E. Lynch, Tiara S. Napier, Ameer Mansur, Benjamin M. Larimer, Suzanne E. Lapi, Ariella B. Hanker, Anna G. Sorace
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2024-06-01
Серія:	Breast Cancer Research
Предмети:	89Zr MMTV-HER2 4T1 PD-1 CTLA4 Spleen
Онлайн доступ:	https://doi.org/10.1186/s13058-024-01844-3
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