New In Vitro Methodology for Kinetics Distribution Prediction in the Brain. An Additional Step towards an Animal-Free Approach

The development of new drugs or formulations for central nervous system (CNS) diseases is a complex pharmacologic and pharmacokinetic process; it is important to evaluate their access to the CNS through the blood–brain barrier (BBB) and their distribution once they have acceded to the brain. The gol...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Bárbara Sánchez-Dengra, Isabel González-Álvarez, Marta González-Álvarez, Marival Bermejo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-12-01
coleção:	Animals
Assuntos:	blood–brain barrier (BBB) unbound fraction (f<sub>u</sub>) distribution volume in brain (V<sub>u,brain</sub>) 3Rs
Acesso em linha:	https://www.mdpi.com/2076-2615/11/12/3521
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!