New In Vitro Methodology for Kinetics Distribution Prediction in the Brain. An Additional Step towards an Animal-Free Approach

The development of new drugs or formulations for central nervous system (CNS) diseases is a complex pharmacologic and pharmacokinetic process; it is important to evaluate their access to the CNS through the blood–brain barrier (BBB) and their distribution once they have acceded to the brain. The gol...

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Egile Nagusiak:	Bárbara Sánchez-Dengra, Isabel González-Álvarez, Marta González-Álvarez, Marival Bermejo
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2021-12-01
Saila:	Animals
Gaiak:	blood–brain barrier (BBB) unbound fraction (f<sub>u</sub>) distribution volume in brain (V<sub>u,brain</sub>) 3Rs
Sarrera elektronikoa:	https://www.mdpi.com/2076-2615/11/12/3521
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