Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination

Abstract Solid tumor malignancy (STM) patients experience increased risk of breakthrough SARS-CoV-2 infection owing to reduced COVID-19 vaccine immunogenicity. However, the underlying immunological causes of impaired neutralization remain poorly characterized. Furthermore, non-neutralizing antibody...

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Principais autores:	Ruth A. Purcell, Marios Koutsakos, Lukasz Kedzierski, Lilith F. Allen, Oscar H. Lloyd Williams, Jo-Wai Douglas Wang, George Cavic, Adam K. Wheatley, Wen Shi Lee, Bruce D. Wines, P. Mark Hogarth, Emily M. Eriksson, Ivo Mueller, Katherine A. Bond, Deborah A. Williamson, Janine M. Trevillyan, Jason A. Trubiano, Thi H. O. Nguyen, Pradhipa Ramanathan, Stephen J. Rogerson, Kelly B. Arnold, Kanta Subbarao, Adrian Lee, Amanda L. Hudson, Alexander Yuile, Helen R. Wheeler, Stephen J. Kent, Kevin John Selva, Siddhartha Mahanty, Katherine Kedzierska, Aude M. Fahrer, Yada Kanjanapan, Amy W. Chung
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-10-01
coleção:	npj Vaccines
Acesso em linha:	https://doi.org/10.1038/s41541-025-01268-w
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