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High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures. Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium using th...

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Bibliografiske detaljer
Principais autores: Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2022-09-01
Serier:eLife
Fag:
Online adgang:https://elifesciences.org/articles/79843
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