Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes

During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β’s signaling pathways can contribute to a hypertrophy(-like) phenotype in chondrocytes, especially at high doses of TGF-β. In this study, we examine which transcription factors (TFs) are activated and i...

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Bibliografische gegevens

Hoofdauteurs:	Nathalie G. M. Thielen, Margot Neefjes, Elly L. Vitters, Henk M. van Beuningen, Arjen B. Blom, Marije I. Koenders, Peter L. E. M. van Lent, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Arjan P. M. van Caam, Peter M. van der Kraan
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2022-04-01
Reeks:	Cells
Onderwerpen:	chondrocyte hypertrophy TGF-β osteoarthritis transcription factors ALK5
Online toegang:	https://www.mdpi.com/2073-4409/11/7/1232
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