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Gut-heart immuno-metabolic disruption associated with inflammaging and subclinical coronary artery disease in people with HIV on antiretroviral therapy

Abstract Background Despite antiretroviral therapy (ART), people with HIV (PWH) face immunological ageing and accelerated comorbidities including coronary artery disease (CAD). Gut mucosal damage, chronic inflammation, and Tryptophan (Trp) catabolism into Kynurenine (Kyn) by indoleamine 2,3-dioxygen...

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Principais autores: Ana-Karla Diego-Matos, Kayluz Frias Boligan, Ralph-Sydney Mboumba Bouassa, Madeleine Durand, Cecile Tremblay, Carl Chartrand-Lefebvre, Mohamed El-Far, Marc Messier-Peet, Justine Giffard-Bouvier, Shari Margolese, Petronela Ancuta, Ido Kema, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Immunity & Ageing
Fag:
HIV
Inflammaging
Coronary artery disease
Immuno-metabolism
Indoleamine 2,3-dioxygenase 1 (IDO1)
Tryptophan
Online adgang:https://doi.org/10.1186/s12979-026-00566-8
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