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Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy

Abstract Background Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation. Indoleamine 2,3-dioxygenase is expressed in many cancer types, including breast cancer. Here, we analyze kynurenine and...

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Principais autores: Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours, Guy Jerusalem
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-07-01
coleção:Journal of Translational Medicine
Assuntos:
Indoleamine 2,3-dioxygenase
Kynurenine
Tryptophan
Kynurenine/tryptophan ratio
Immune system
Breast cancer
Acesso em linha:http://link.springer.com/article/10.1186/s12967-019-1984-2
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