The impact of PrsA over-expression on the Bacillus subtilis transcriptome during fed-batch fermentation of alpha-amylase production

The production of the alpha-amylase (AMY) enzyme in Bacillus subtilis at a high rate leads to the accumulation of unfolded AMY, which causes secretion stress. The over-expression of the PrsA chaperone aids enzyme folding and reduces stress. To identify affected pathways and potential mechanisms invo...

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Hlavní autoři:	Adrian S. Geissler, Line D. Poulsen, Nadezhda T. Doncheva, Christian Anthon, Stefan E. Seemann, Enrique González-Tortuero, Anne Breüner, Lars J. Jensen, Carsten Hjort, Jeppe Vinther, Jan Gorodkin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-08-01
Edice:	Frontiers in Microbiology
Témata:	alpha-amylase PrsA Bacillus subtilis RNA sequencing (RNA-seq) enzyme produced by microorganism
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.909493/full
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