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The repertoire of resistance mutations selected by a Pseudomonas aeruginosa type IV pilus-targeting lytic bacteriophage

ABSTRACT Pseudomonas aeruginosa type IV pili (T4P) are complex surface-exposed nanomachines used for twitching motility and biofilm formation. Exposure to bacteriophages that use T4P as their primary receptor can select for resistance mutations that reduce or abolish pilus expression. Since T4P are...

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Principais autores: Veronica N. Tran, Hanjeong Harvey, Tanisha S. Lahane, Lori L. Burrows
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-05-01
Serier:mBio
Fag:
bacteriophages
bacteriophage therapy
Pseudomonas aeruginosa
type IV pili
antibiotic resistance
type II secretion
Online adgang:https://journals.asm.org/doi/10.1128/mbio.00243-26
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