IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members

Summary: Immunoglobulin E (IgE)-dependent mast cell degranulation and anaphylaxis are suppressed by the CD300f-ceramide interaction. However, the related, positive regulatory mechanisms remain unclear. Here, we examine the effect of FcεRIγ-coupled CD300d3 on IgE-dependent anaphylaxis in mice. We ide...

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Autori principali:	Kumi Izawa, Ayako Kaitani, Yutaka Enomoto, Tomoaki Ando, Yuka Yasuda, Tomoaki Kahyo, Akie Maehara, Risa Yamamoto, Natsumi Uchida, Yuka Furuichi, Kaiyan Wei, Hiromichi Yamada, Yu Kawasumi, Takuma Ide, Masahiro Nakamura, Shino Uchida, Nobuhiro Nakano, Junko Ishikawa, Hiroshi Kiyonari, Takaya Abe, Toshiaki Shimizu, Toshio Kitamura, Hideoki Ogawa, Ko Okumura, Mitsutoshi Setou, Jiro Kitaura
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Cell Reports
Soggetti:	CP: immunology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124726001324
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