NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis

Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA bridging because of telomere dysfunction. NEIL3 expressio...

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Detalles Bibliográficos

Principais autores:	Jia Zhou, Jany Chan, Marie Lambelé, Timur Yusufzai, Jason Stumpff, Patricia L. Opresko, Markus Thali, Susan S. Wallace
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2017-08-01
Series:	Cell Reports
Assuntos:	NEIL3 glycosylase telomere mitotic defects DNA repair
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124717311129
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