NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis

Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA bridging because of telomere dysfunction. NEIL3 expressio...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jia Zhou, Jany Chan, Marie Lambelé, Timur Yusufzai, Jason Stumpff, Patricia L. Opresko, Markus Thali, Susan S. Wallace
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2017-08-01
Sarja:	Cell Reports
Aiheet:	NEIL3 glycosylase telomere mitotic defects DNA repair
Linkit:	http://www.sciencedirect.com/science/article/pii/S2211124717311129
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