Targeting mitochondrial fission-autophagy axis in rheumatoid arthritis: leflunomide promote apoptosis of fibroblast-like synoviocytes

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint destruction, driven by aberrantly activated fibroblast-like synoviocytes (RA-FLS). Mitochondrial dysfunction, particularly excessive mitochondrial fission, contributes to RA-FLS activat...

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Hauptverfasser:	Xiaoxue Wang, Jianling Su, Shiqi Feng, Jiaqi Qu, Wei Jiang, Jiping Chen, Xuemei Fan, Yongmei Yu, Jiayi Luo, Yang Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-05-01
Schriftenreihe:	Arthritis Research & Therapy
Schlagworte:	Rheumatoid arthritis Mitochondrial fission Leflunomide Methotrexate Fibroblast-like synoviocytes
Online-Zugang:	https://doi.org/10.1186/s13075-026-03828-4
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