Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes

Rheumatoid arthritis (RA) is a challenging autoimmune disorder characterized by fibroblast-like synoviocyte (FLS)-driven synovitis and joint destruction. Halofuginone (HF), a bioactive derivative of febrifugine isolated from the root of Dichroa febrifuga Lour., exhibits therapeutic potential in RA y...

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Autores principales:	Yuanyuan Tang, Han Wu, Ping Yan, Zhangxuan Yue, Zeyu Hu, Xunqi Liao, Yali Wang, Ye Lin, Liqing Li, Xiong Cai
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-06-01
Colección:	Pharmacological Research
Materias:	Rheumatoid arthritis Fibroblast-like synoviocytes Halofuginone HSPA8 Adjuvant-induced arthritis
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1043661825001872
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