Development of CRISPR/Cas9-mediated CD16b-/- and CD32a-/- promyelocytic cell lines to study FcγR signaling in human neutrophils
IntroductionNeutrophils use Fc gamma receptors (FcγRs) to recognize IgG-opsonized pathogens, triggering antimicrobial functions including phagocytosis, ROS production, and cytokine release. CD16b, the most abundant FcγR on neutrophils, plays a key role in initiating these responses, while CD32a is a...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2025-10-01
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| Schriftenreihe: | Frontiers in Immunology |
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| Online-Zugang: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1633609/full |
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