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Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor

The chemokine receptor CCR5 is a key player in HIV-1 infection. The cryo-EM 3D structure of HIV-1 envelope glycoprotein (Env) subunit gp120 in complex with CD4 and CCR5 has provided important structural insights into HIV-1/host cell interaction, yet it has not explained the signaling properties of E...

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Principais autores: Célien Jacquemard, Florian Koensgen, Philippe Colin, Bernard Lagane, Esther Kellenberger
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-07-01
Serier:Viruses
Fag:
viral entry
GPCR
flexibility
conformation
binding mode
Online adgang:https://www.mdpi.com/1999-4915/13/7/1395
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