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Schistosoma japonicum peptide SJMHE1 promotes peripheral nerve regeneration via macrophage migrasome-derived miR-26b-5p targeting the PTEN/AKT axis

Abstract Background Peripheral nerve injury (PNI) is a major clinical challenge with limited effective therapeutic options. Our prior work has demonstrated that SJMHE1, a peptide derived from Schistosoma japonicum, promotes peripheral nerve regeneration by regulating M2 macrophages; however, its dow...

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Principais autores: Qian Wang, Wei Zhang, Kai Zhao, Yue Liu, Shang Wang, Xingwen Chen, Dan Zhou, Juan Wang, Yu Feng, Tao Li, Wenchao Zhang, Liyang Dong, Yongbin Ma
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:Journal of Translational Medicine
Fag:
Schistosoma japonicum peptide
SJMHE1
Macrophages
Migrasome
Schwann cells
miR-26b-5p
Online adgang:https://doi.org/10.1186/s12967-025-07328-y
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