Schistosoma japonicum peptide SJMHE1 promotes peripheral nerve regeneration via macrophage migrasome-derived miR-26b-5p targeting the PTEN/AKT axis

Abstract Background Peripheral nerve injury (PNI) is a major clinical challenge with limited effective therapeutic options. Our prior work has demonstrated that SJMHE1, a peptide derived from Schistosoma japonicum, promotes peripheral nerve regeneration by regulating M2 macrophages; however, its dow...

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Autori principali:	Qian Wang, Wei Zhang, Kai Zhao, Yue Liu, Shang Wang, Xingwen Chen, Dan Zhou, Juan Wang, Yu Feng, Tao Li, Wenchao Zhang, Liyang Dong, Yongbin Ma
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-11-01
Serie:	Journal of Translational Medicine
Soggetti:	Schistosoma japonicum peptide SJMHE1 Macrophages Migrasome Schwann cells miR-26b-5p
Accesso online:	https://doi.org/10.1186/s12967-025-07328-y
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