A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene

Gene editing utilizing homology-directed repair has advanced significantly for many monogenic diseases of the hematopoietic system in recent years but has also been hindered by decreases between in vitro and in vivo gene integration rates. Homology-directed repair occurs primarily in the S/G2 phases...

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Principais autores:	David H. Gray, Jasmine Santos, Alexandra Grace Keir, Isaac Villegas, Simon Maddock, Edward C. Trope, Joseph D. Long, Caroline Y. Kuo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-03-01
coleção:	Molecular Therapy: Nucleic Acids
Assuntos:	gene editing CRISPR-Cas9 X-linked agammaglobulinemia homology-directed repair HDR homology-independent targeted integration
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2162253121003176
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