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Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

Retinoic acid inducible gene-I (RIG-I) is a cytosolic pathogen recognition receptor that initiates the immune response against many RNA viruses. Upon RNA ligand binding, RIG-I undergoes a conformational change facilitating its homo-oligomerization and activation that results in its translocation fro...

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Principais autores: Helene Minyi Liu, Fuguo Jiang, Yueh Ming Loo, ShuZhen Hsu, Tien-Ying Hsiang, Joseph Marcotrigiano, Michael Gale Jr.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-07-01
Serier:EBioMedicine
Fag:
RIG-I
HDAC6
Deacetylation
HCV
West Nile virus
Interferon
Innate immunity
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396416302596
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