Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1

Abstract TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered. We show here that during the early stage of viral infectio...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jie-lin Tang, Qi Yang, Chong-hui Xu, He Zhao, Ya-ling Liu, Can-yu Liu, Yuan Zhou, Dong-wei Gai, Rong-juan Pei, Yun Wang, Xue Hu, Bo Zhong, Yan-yi Wang, Xin-wen Chen, Ji-zheng Chen
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Oxford University Press 2020-08-01
Цуврал:	Protein & Cell
Нөхцлүүд:	TBK1 HDAC3 deacetylation IRF3 innate immune
Онлайн хандалт:	https://doi.org/10.1007/s13238-020-00751-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!