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Trait selection strategy in multi-trait GWAS: Boosting SNP discoverability

Summary: Since the first genome-wide association studies (GWASs), thousands of variant-trait associations have been discovered. However, comprehensively mapping the genetic determinant of complex traits through univariate testing can require prohibitive sample sizes. Multi-trait GWAS can circumvent...

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Збережено в:
Автори: Yuka Suzuki, Hervé Ménager, Bryan Brancotte, Raphaël Vernet, Cyril Nerin, Christophe Boetto, Antoine Auvergne, Christophe Linhard, Rachel Torchet, Pierre Lechat, Lucie Troubat, Michael H. Cho, Emmanuelle Bouzigon, Hugues Aschard, Hanna Julienne
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2024-07-01
Серія:HGG Advances
Предмети:
Complex traits
Variant mapping
Multi-trait GWAS
Statistical power
Genetic Architecture
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2666247724000587
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