Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores

Summary: Publicly available genome-wide association studies (GWAS) summary statistics exhibit uneven quality, which can impact the validity of follow-up analyses. First, we present an overview of possible misspecifications that come with GWAS summary statistics. Then, in both simulations and real-da...

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Detalhes bibliográficos

Principais autores:	Florian Privé, Julyan Arbel, Hugues Aschard, Bjarni J. Vilhjálmsson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-10-01
coleção:	HGG Advances
Assuntos:	GWAS summary statistics misspecifications polygenic scores
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666247722000525
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