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Distinctive expression of Bcl-2 factors in regulatory T cells determines a pharmacological target to induce immunological tolerance

Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells. Targeted pharmacological modulation of this pathway...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sarah Sharon Gabriel, Nina eBon, Jin eChen, Thomas eWekerle, Andrew eBushell, Thomas eFehr, Pietro Ernesto Cippà
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016-03-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
Apoptosis
Transplantation
tolerance
regulatory T cells
Bcl-2
GvHD
Online-Zugang:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00073/full
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