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α-Synuclein oligomers form by secondary nucleation

Abstract Oligomeric species arising during the aggregation of α-synuclein are implicated as a major source of toxicity in Parkinson’s disease, and thus a major potential drug target. However, both their mechanism of formation and role in aggregation are largely unresolved. Here we show that, at phys...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Catherine K. Xu, Georg Meisl, Ewa A. Andrzejewska, Georg Krainer, Alexander J. Dear, Marta Castellana-Cruz, Soma Turi, Irina A. Edu, Giorgio Vivacqua, Raphaël P. B. Jacquat, William E. Arter, Maria Grazia Spillantini, Michele Vendruscolo, Sara Linse, Tuomas P. J. Knowles
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-08-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-024-50692-4
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