Small heterodimer partner (SHP) aggravates ER stress in Parkinson’s disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation

Abstract Background Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation in the PD-associated gene LRRK2, cause ER dysfunction, and could thereb...

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Hlavní autoři:	Jee Hoon Lee, Ji-hye Han, Eun-hye Joe, Ilo Jou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-07-01
Edice:	Journal of Biomedical Science
Témata:	Parkinson’s diseases LRRK2 ER stress Astrocytes XBP1 SUMOylation
On-line přístup:	https://doi.org/10.1186/s12929-021-00747-1
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