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Small heterodimer partner (SHP) aggravates ER stress in Parkinson’s disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation

Abstract Background Endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation in the PD-associated gene LRRK2, cause ER dysfunction, and could thereb...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jee Hoon Lee, Ji-hye Han, Eun-hye Joe, Ilo Jou
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2021-07-01
Schriftenreihe:Journal of Biomedical Science
Schlagworte:
Parkinson’s diseases
LRRK2
ER stress
Astrocytes
XBP1
SUMOylation
Online-Zugang:https://doi.org/10.1186/s12929-021-00747-1
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