Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design.

The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret data has not been conducted, perhaps due to insuf...

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Hlavní autoři:	Micaela B Reddy, Kuo-Hsiung Yang, Gauri Rao, Craig R Rayner, Jing Nie, Chandrasena Pamulapati, Bindumadhav M Marathe, Alan Forrest, Elena A Govorkova
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2015-01-01
Edice:	PLoS ONE
On-line přístup:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138069&type=printable
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