Understanding the Monoclonal Antibody Disposition after Subcutaneous Administration using a Minimal Physiologically based Pharmacokinetic Model
Purpose: Monoclonal antibodies (mAbs) are commonly administered by subcutaneous (SC) route. However, bioavailability is often reduced after SC administration. In addition, the sequential transfer of mAbs through the SC tissue and lymphatic system is not completely understood. Therefore, major object...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2018-07-01
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| Schriftenreihe: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online-Zugang: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30028 |
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