The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination

HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. HMGB1 is normally localized to the nucleus, where it acts as a chromatin associated non-histone binding protein. In contrast, extracellular HMGB1 is an alarmin released by stressed cells to act as a danger associated molecular patt...

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Auteurs principaux:	Megan E. Rouillard, Jingwen Hu, Pearl A. Sutter, Hee Won Kim, Jeffrey K. Huang, Stephen J. Crocker
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-04-01
Collection:	Frontiers in Cellular Neuroscience
Sujets:	cellular senescence myelin multiple sclerosis lysolecithin (LPC) microglia TLR2
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fncel.2022.833186/full
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