Slice of Life: Porcine Kidney Slices for Testing Antifibrotic Drugs in a Transplant Setting

Circulatory death donor (DCD) kidneys are increasingly used to enlarge the donor pool. These kidneys undergo ischemia-reperfusion injury, frequently leading to renal fibrosis. Transforming growth factor beta 1 (TGF-β1) and matrix metalloproteases have been identified as central mediators of fibrosis...

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Auteurs principaux:	L. Leonie van Leeuwen, Mitchel J. R. Ruigrok, Henri G. D. Leuvenink, Peter Olinga
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2023-04-01
Collection:	Transplantology
Sujets:	donation after circulatory death kidney transplantation ischemia-reperfusion injury fibrosis normothermic machine perfusion precision-cut kidney slices
Accès en ligne:	https://www.mdpi.com/2673-3943/4/2/7
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