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Peptidomimetic blockade of MYB in acute myeloid leukemia

MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.

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Autores principales: Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2018-01-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-017-02618-6
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