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Trophoblast cell surface antigen 2 (TROP2) from ascitic extracellular vesicles drives peritoneal metastasis of ovarian cancer by mesothelial-to-mesenchymal transition

Abstract Background Ovarian cancer (OvCA) exhibits a distinctive tendency toward peritoneal metastasis, a pathological process that greatly affects disease progression and postoperative recurrence. Understanding the biological mechanisms underlying this metastatic cascade is critical for improving p...

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Principais autores: Guangyan Xie, Guanfeng Chen, Wenqiang Lv, Wei Tai, Bei Zhang, Xueyan Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:Journal of Ovarian Research
Fag:
Ovarian cancer
TROP2
Extracellular vesicles
Peritoneal metastasis
Mesothelial-to-mesenchymal transition
Online adgang:https://doi.org/10.1186/s13048-025-01845-6
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