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An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics

Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating. In this study, we aim to demonstrate that depth of analysis can be combined with acceptab...

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Principais autores: Peter Lukacs, Krisztina Pesti, Mátyás C. Földi, Katalin Zboray, Adam V. Toth, Gábor Papp, Arpad Mike
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-09-01
Serier:Frontiers in Pharmacology
Fag:
automated patch-clamp
sodium channel inhibitor
binding kinetics
epilepsy
pain
neuromuscular disorders
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2021.738260/full
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