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Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination

Abstract Background Ageing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19+ B cells such as follicular B cells (FOB) and an accumulation of age-associated B cells (ABC) or activated B cell subsets. This remodeling is thought to confer an attenuated antibody...

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Principais autores: Paul Kunath, Dominik Pflumm, Bettina Moehrle, Vadim Sakk, Alina Seidel, Jan Münch, Hartmut Geiger, Reinhold Schirmbeck
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-04-01
Serier:Immunity & Ageing
Fag:
Hematopoietic stem cells
Old immune system
B cells
SARS-CoV-2 spike vaccine
IgG antibody response
Online adgang:https://doi.org/10.1186/s12979-025-00507-x
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