Development and Validation of a Method for the Semi-Quantitative Determination of <i>N</i>-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector
A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic <i>N</i>-nitrosodimethylamine (NDMA) and <i>N</i>-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate. <i>N</i>-nitrosamines were subject to denitrosation foll...
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| Principais autores: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI AG
2021-08-01
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| Serier: | Applied Sciences |
| Fag: | |
| Online adgang: | https://www.mdpi.com/2076-3417/11/16/7590 |
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