Development and Validation of a Method for the Semi-Quantitative Determination of <i>N</i>-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic <i>N</i>-nitrosodimethylamine (NDMA) and <i>N</i>-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate. <i>N</i>-nitrosamines were subject to denitrosation foll...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Dariusz Boczar, Elżbieta Wyszomirska, Beata Zabrzewska, Anna Chyła, Katarzyna Michalska
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2021-08-01
Sarja:	Applied Sciences
Aiheet:	<i>N</i>-nitrosamine NDMA NDEA enalapril Fmoc-Cl
Linkit:	https://www.mdpi.com/2076-3417/11/16/7590
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