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The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities

Abstract The cGAS-STING pathway acts as a critical molecular hub connecting genomic instability with cellular senescence. Functioning as a key regulator of the innate immune system, this pathway detects aberrant cytoplasmic DNA to activate downstream inflammatory responses, thereby playing a pivotal...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Shiqing Tan, Eugenie Nepovimova, Marian Valko, Klaudia Jomova, Qinghua Wu, Kamil Kuca
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2026-04-01
Rangatū:Cell Communication and Signaling
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s12964-026-02855-7
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