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NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway

Abstract Posttraumatic osteoarthritis (PTOA) is closely related to the inflammatory response caused by mechanical injury and leads to joint degeneration. Herein, we aimed to evaluate the role and underlying mechanism of NUMB in PTOA progression. Anterior cruciate ligament transection (ACLT)-induced...

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Principais autores: Zhou Lv, Yuan Ding, Wei Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:Journal of Orthopaedic Surgery and Research
Assuntos:
Posttraumatic osteoarthritis
NUMB
BTRC
NF-κB
Inflammation
Acesso em linha:https://doi.org/10.1186/s13018-024-04967-7
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