RIPK1 regulates β-cell fate via actions on gene expression and kinase signaling in a mouse model of β-cell self-reactivity

Abstract Type 1 diabetes (T1D) is characterized by autoimmune destruction of pancreatic β-cells, insulin insufficiency, and hyperglycemia. Receptor interacting protein kinase 1 (RIPK1) is a multifunctional regulator of cell fate with kinase and scaffolding functions, and we previously identified RIP...

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Detalles Bibliográficos

Principais autores:	Christopher J. Contreras, Noyonika Mukherjee, Arianna Harris-Kawano, Egan G. Mather, Nansalmaa Amarsaikhan, Christopher Davis, Christine A. Berryhill, Madeline Peyton, Debjyoti Kundu, Kaitlyn A. Colglazier, Addison S. Miller, Renato C. S. Branco, Travis S. Johnson, Steven P. Angus, Sylvaine You, Erica P. Cai, Andrew T. Templin
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2026-02-01
Series:	Cell Death and Disease
Acceso en liña:	https://doi.org/10.1038/s41419-026-08471-0
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