Exploring the inhibitory mechanism of resorcinylic isoxazole amine NVP-AUY922 towards the discovery of potential heat shock protein 90 (Hsp90) inhibitors

Heat shock protein 90 (Hsp90) is an ATP-dependant molecular chaperone that facilitates protein maturation while protecting cancer cells from temperature-induced stress. Hsp90, therefore, remains an attractive target for anticancer drug development. The study aimed to use multidimensional computation...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Ayanda M. Magwenyane, Monsurat M. Lawal, Daniel G. Amoako, Anou M. Somboro, Clement Agoni, Rene B. Khan, NdumisoN. Mhlongo, Hezekiel M. Kumalo
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2022-03-01
Rangatū:	Scientific African
Ngā marau:	Pharmacophore-based virtual screening Molecular docking Molecular dynamics ONIOM method Hsp90 N-terminal NVP-AUY922
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2468227622000163
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!