Bioorthogonal Reaction of o‐Quinone with Furan‐2(3H)‐One for Site‐Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes

Abstract Bioorthogonal reactions enable the chemical conjugation of functional moieties to native proteins and empower the development of new diagnostic tools and therapeutics. Through site‐selective reactions, therapeutic molecules can be conjugated with antibodies in a stoichiometry‐ and site‐cont...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Hongfei Chen, Zhiyi Xu, Yishu Bao, Farshad Shiri, Dingdong Yuan, Yuke Hu, Biquan Li, Bin Zeng, Xiaojing Li, Hao Kong, Zikang Wang, Wilson Chun‐Yu Lau, Zhenyang Lin, Jiang Xia
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2025-06-01
Sarja:	Advanced Science
Aiheet:	antibody conjugation antibody‐dependent cellular cytotoxicity bispecific antibody complex o‐quinone tyrosine reaction
Linkit:	https://doi.org/10.1002/advs.202417260
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