Bioorthogonal Reaction of o‐Quinone with Furan‐2(3H)‐One for Site‐Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes

Abstract Bioorthogonal reactions enable the chemical conjugation of functional moieties to native proteins and empower the development of new diagnostic tools and therapeutics. Through site‐selective reactions, therapeutic molecules can be conjugated with antibodies in a stoichiometry‐ and site‐cont...

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Bibliografische gegevens

Hoofdauteurs:	Hongfei Chen, Zhiyi Xu, Yishu Bao, Farshad Shiri, Dingdong Yuan, Yuke Hu, Biquan Li, Bin Zeng, Xiaojing Li, Hao Kong, Zikang Wang, Wilson Chun‐Yu Lau, Zhenyang Lin, Jiang Xia
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2025-06-01
Reeks:	Advanced Science
Onderwerpen:	antibody conjugation antibody‐dependent cellular cytotoxicity bispecific antibody complex o‐quinone tyrosine reaction
Online toegang:	https://doi.org/10.1002/advs.202417260
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