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Fragment ion intensity prediction improves the identification rate of non-tryptic peptides in timsTOF

Abstract Immunopeptidomics is crucial for immunotherapy and vaccine development. Because the generation of immunopeptides from their parent proteins does not adhere to clear-cut rules, rather than being able to use known digestion patterns, every possible protein subsequence within human leukocyte a...

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Principais autores: Charlotte Adams, Wassim Gabriel, Kris Laukens, Mario Picciani, Mathias Wilhelm, Wout Bittremieux, Kurt Boonen
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2024-05-01
Serija:Nature Communications
Online dostop:https://doi.org/10.1038/s41467-024-48322-0
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