The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized Hot-Melt Granulation—From the Lab Scale to the Pilot Scale

Solid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior. Robust computational tools, via data mining, offer valuable insights into product performance, complementing traditional methods...

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Detalhes bibliográficos

Principais autores:	Béla Kovács, Erzsébet-Orsolya Tőkés, Éva Katalin Kelemen, Katalin Zöldi, Francisc Boda, Edit Suba, Boglárka Kovács-Deák, Tibor Casian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-03-01
coleção:	Pharmaceutics
Assuntos:	design of experiments multivariate data analysis fluidized hot-melt granulation pharmaceutical process scale-up pharmaceutical development
Acesso em linha:	https://www.mdpi.com/1999-4923/16/3/391
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