A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer

Abstract Background Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin. The objective of the trial was to test the efficacy of trans-tympanic injections of a STS gel to prevent cisplatin-induced ototoxicity. Me...

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Hlavní autoři:	Viannique Rolland, François Meyer, Matthieu J. Guitton, Richard Bussières, Daniel Philippon, Isabelle Bairati, Mathieu Leclerc, Mathieu Côté
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	SAGE Publishing 2019-01-01
Edice:	Journal of Otolaryngology - Head and Neck Surgery
Témata:	Head and neck cancer Cisplatin Ototoxicity Trans-tympanic injection Sodium thiosulfate Quality of life
On-line přístup:	http://link.springer.com/article/10.1186/s40463-019-0327-x
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