Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1α ER Stress Signaling

Overdose of acetaminophen (APAP) can cause severe liver injury. Although alcohol is considered a risk factor for APAP toxicity, the mechanism underlying the interaction between alcohol and APAP remains unclear. Binge alcohol (5 g/kg every 12 h, 3 doses) reduced the concentration of cysteine and glut...

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Autori principali:	Sou Hyun Kim, Hun Ji Choi, Hyeji Seo, Doyoung Kwon, Jaesuk Yun, Young-Suk Jung
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-12-01
Serie:	Antioxidants
Soggetti:	acetaminophen alcohol liver injury glutathione endoplasmic reticulum stress
Accesso online:	https://www.mdpi.com/2076-3921/10/12/1949
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