Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1α ER Stress Signaling

Overdose of acetaminophen (APAP) can cause severe liver injury. Although alcohol is considered a risk factor for APAP toxicity, the mechanism underlying the interaction between alcohol and APAP remains unclear. Binge alcohol (5 g/kg every 12 h, 3 doses) reduced the concentration of cysteine and glut...

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Ngā kaituhi matua:	Sou Hyun Kim, Hun Ji Choi, Hyeji Seo, Doyoung Kwon, Jaesuk Yun, Young-Suk Jung
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2021-12-01
Rangatū:	Antioxidants
Ngā marau:	acetaminophen alcohol liver injury glutathione endoplasmic reticulum stress
Urunga tuihono:	https://www.mdpi.com/2076-3921/10/12/1949
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!